Heegwang Roh

Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo

This paper introduces LATeNT, a light-activated tetanus neurotoxin that enables conditional proteolysis and inducible synaptic inhibition in vivo, with applications in neuroscience and beta cell function.

Systemic degradation of repressive transcription factors gates gene expression and cell fate specification

The paper shows proteasomes degrade repressive transcription factors, freeing chromatin for activator binding and enabling gene expression and cell fate decisions.

Metabolic glues as a means of purine sensing and chemotherapeutic response

This study identifies purine nucleotides as molecular glues that regulate purine biosynthesis by tethering PPAT to NUDT5, and shows how thiopurine drugs function as metabolic glues with enhanced potency.

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells

This paper introduces LOV-Turbo, a light-regulated proximity labeling tool that enhances spatial and temporal control of proteomic mapping in living cells.