Tal Iram

An atlas of the aging glycoproteome reveals how glycosylation modulates autoantibody binding in the brain

The paper maps age-related changes in the N-glycoproteome across multiple tissues in mice, showing how glycosylation affects autoantibody binding to MOG in the brain.

Sex-divergent responses to microglial depletion suggest distinct regulatory dependencies in the aged brain

This study identifies sex-dimorphic molecular responses to microglial depletion in aged mice, highlighting differences in transcriptional and proteomic changes between males and females.

Domain-specific proteome remodeling defines mouse myelin aging

This study identifies age- and sex-related changes in the mouse myelin proteome, revealing increased structural proteins and decreased cytoskeletal and synaptic proteins with aging.

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

The paper identifies lipid droplet-accumulating microglia (LAM) as a dysfunctional, pro-inflammatory state in aging brains, linked to neurodegeneration.

Astrocyte senescence in an Alzheimer’s disease mouse model is mediated by TGF-β1 and results in neurotoxicity

This study shows that astrocyte senescence in Alzheimer’s disease mice is driven by TGF-β1 and contributes to neurotoxicity.