Xuemei Wen

The paper shows ATM deficiency leads to transcription-associated lesions, affecting cerebellum function and causing neurodegeneration through changes in transcription and PARylation.

This study shows that phosphorylation of Hsp70 at Ser151 by Cdk1 during growth reduces its chaperone activity and affects stress responses and prion maintenance.

This study shows that Sae2/CtIP prevents R-loop accumulation by facilitating their removal, with CtIP nuclease activity playing a critical role in this process.