Amy Kontorovich

The paper explores patient and clinician perspectives on identifying and managing the underlying causes of severe hypercholesterolemia through genomic insights.

This study identifies IgG's pro-atherogenic role through noncanonical activation of macrophages, independent of its classical function, by acting as a TLR4 ligand and promoting inflammation.

This study identifies 25 cellular subsets in thoracic aortic aneurysm tissue and links FGF-23 as a plasma biomarker associated with aortic diameter and disease.

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

This study assesses dysautonomia prevalence and its association with exercise intolerance and cardiac atrophy in patients with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.