Anna C. Geraghty

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.

This study shows that housing facility and time of day affect MTX-induced chemotoxicity in mice through changes in gut microbiome and inflammatory responses.

This study identifies the NLGN3-CSPG4-PIEZO1 axis as a regulator of glial precursor cell state and glioma proliferation through mechanosensitive signaling.

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

This study identifies functional GABAergic neuron-to-glioma synapses in diffuse midline gliomas that promote tumor proliferation and shows that drugs modulating GABAergic signaling affect glioma growth.

This study shows that BDNF-TrkB signaling promotes malignant synaptic plasticity in gliomas, enhancing tumor progression through mechanisms similar to long-term potentiation in the healthy brain.

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.