Oleic acid suppresses NLRP3 inflammasome activation to prevent dermal macrophage death and limit imiquimod-induced psoriasis
Beatriz Burger, Roberta Nicolli Sagiorato, Isabela Buquio Baccarin, Vítor Rosetto Muñoz, Gabriella Cerna, Ilya Andreev, Nathalia Araujo, Hui Sophie Shu, Jia Zhao, Brandon Sullivan, Yisha Liang, Rodrigo Angelo Martinati Bistaffa, Vitoria Christina Gaspar, Esther Midori Yabuuti, Natalie Bittencourt Ramos, , Hosana Gomes Rodrigues
This study shows that oleic acid reduces NLRP3 inflammasome activity in macrophages, preventing their death and limiting psoriasis-like skin inflammation in mice.
bioRxiv · Nov 1, 2026 · PreprintImmunology