Bruce A. Edgar

Mating and ecdysone signaling modify growth, metabolism, and digestive efficiency in the female Drosophila gut

This study shows mating in Drosophila females alters gut metabolism, digestive efficiency, and gene expression, with ecdysone signaling playing a key role in these changes.

Rare codon translation regulates growth factor-dependent cell proliferation

The paper shows that growth factor signaling promotes cell proliferation by inducing tRNAs that decode rare codons, enhancing translation of DNA replication factors.

A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut

The paper shows that bHLH transcription factor interactions regulate stemness and bipotential differentiation in Drosophila gut stem cells.

Bwa, an ortholog of alkaline ceramidase-ACER2, promotes intestinal stem cell proliferation through pro-inflammatory cytokine signaling in Drosophila melanogaster

This study identifies Bwa as a regulator of intestinal stem cell proliferation in Drosophila through pro-inflammatory cytokine signaling, linking sphingolipid metabolism to gut homeostasis.