Priscilla L. Yang

This study shows membrane binding promotes oligomerization and functional activation of HCV NS5B RdRp by inducing a conformational shift that enhances RNA binding.

This paper uses single VLP lipid-mixing measurements and computational modeling to show that dengue virus fusion includes an off-pathway state that is slowly reversible.

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.