Author

Zhixiang He

Harvard UniversityORCID 0000-0002-4493-0336Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

Adam Stuart KibeliD· 1 shared Anne FassliD· 1 shared Antara ChakravartyiD· 1 shared Baishan JiangiD· 1 shared Celine Pana· 1 shared Eric S. FischeriD· 1 shared Fu GuiiD· 1 shared Gary Andrew BradshawiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Adam Stuart KibelORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedApr 23, 2025

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

Fu Gui, Baishan Jiang, Jie Jiang…·Jia Li

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

21 citationstop 2%

humanexperimental assay

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BiochemistryAdvanced SciencePeer-reviewedAug 15, 2024

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Zhengnian Li, Han‐Yuan Liu, Zhixiang He…·Priscilla L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

21 citations

virusexperimental assay

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