Author

Guangyan Du

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Jianwei CheiD· 2 shared Nathanael S. GrayiD· 2 shared Tinghu ZhangiD· 2 shared Antara ChakravartyiD· 1 shared Bingsen ZhangiD· 1 shared Edward T. ChouchaniiD· 1 shared Eric S. FischeriD· 1 shared Evanna L. MillsiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Jianwei CheORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A druggable redox switch on SHP1 controls macrophage inflammation

Mei Ying Ng, Meredith Nicole Nix, Guangyan Du, Ivan Davidek, Nils Burger, Sanghee Shin, Sean T. Toenjes, Haruna Takeda, Megan Cheah Xin Yan, Bingsen Zhang, Haopeng Xiao, Shelley M Wei, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, Thomas E. Wales, , Edward T. Chouchani

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

Nature Chemical Biology · Mar 12, 2026Peer-reviewedBiochemistry

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Zhengnian Li, Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang, Inchul You, Hong Yue, Katherine A. Donovan, Guangyan Du, Jianwei Che, Jason Tse, Isaac Che, Wenchao Lu, Eric S. Fischer, , Priscilla L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Advanced Science · Aug 15, 2024Peer-reviewedBiochemistry