An mRNA-Lipid Nanoparticle Platform Encoding the Conserved Outer Membrane Protein BamA Elicits Broadly Cross-Reactive Systemic and Mucosal Antibodies Against Antimicrobial-Resistant Neisseria gonorrhoeae
Natalie Wolske, Namratha Turuvekere Vittala Murthy, Abhishek Chanda…·Aleksandra E. Sikora
This paper evaluates an mRNA-LNP vaccine encoding BamA against N. gonorrhoeae, showing it elicits cross-reactive antibodies but lacks protective efficacy in mice.