Author

Mackenzie M. Thornton

University of Kansas Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Madhulika SharmaiD· 2 shared Pamela Vivian TraniD· 2 shared Aakriti Chaturvedi· 1 shared Anil Kumar Ram· 1 shared Anubhav ChakrabortyiD· 1 shared Brenda S. Magenheimer· 1 shared Darren P. WallaceiD· 1 shared Dharmalingam SubramaniamiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Madhulika SharmaORCID

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2 papers

Recent·Most cited

Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease

Mackenzie M. Thornton, Nicole Sommer, Mercedes B. Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, Praveen V. Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin C. Singhal, , Madhulika Sharma

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.

Disease Models & Mechanisms · Feb 1, 2025Peer-reviewedMolecular Biology

Quinomycin A reduces cyst progression in Polycystic Kidney Disease

Priyanka S. Radadiya, Mackenzie M. Thornton, Emily A. Daniel, Jessica Y. Idowu, Wei Wang, Brenda S. Magenheimer, Dharmalingam Subramaniam, Pamela Vivian Tran, James P. Calvet, Darren P. Wallace, Madhulika Sharma

This study shows Quinomycin A reduces cyst progression in PKD by inhibiting Notch signaling and normalizing cilia lengths in a mouse model and human cells.

The FASEB Journal · Apr 7, 2021Peer-reviewedGenetics