Krishna Sumanth Ghanta

This study shows that 5' modifications to DNA repair templates enhance precision genome editing efficiency in multiple animal models and human cells.

This study shows that E. coli processing of glucose reduces C. elegans lifespan and healthspan by increasing oxidative stress and decreasing detoxification gene expression.

This paper shows that melting dsDNA donor molecules before injection improves precision genome editing in C. elegans, enabling high-efficiency HDR for long edits.

This paper describes an optimized CRISPR-based genome editing protocol in C. elegans using ssODN and hybrid donors, achieving efficient and reproducible edits for both short and long constructs.