Xiaoyan Qian

SCRINSHOT maps cell states in tissue sections at single-cell resolution, showing high correlation with scRNA-Seq data and enabling detailed spatial analysis of cell types.

This paper introduces HybISS, a spatial transcriptomic method that improves detection flexibility, multiplexing, and signal-to-noise while maintaining throughput efficiency in human and mouse brain tissue.

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

The paper introduces pciSeq to map inhibitory neurons in mouse hippocampus CA1, identifying 16 interneuron classes with spatial arrangement matching ground truth.