Author

Ashley Lu

VIB-KU Leuven Center for Brain & Disease Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Bart De StrooperiD· 3 shared Mark W. E. J. FiersiD· 3 shared Evgenia SaltaiD· 2 shared Katleen CraessaertsiD· 2 shared Nicola ThruppiD· 2 shared Renzo MancusoiD· 2 shared Wei-Ting CheniD· 2 shared Aleksandra Jurek· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Bart De StrooperORCID

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3 papers

Recent·Most cited

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer's Disease

Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Wei-Ting Chen, Mark W. E. J. Fiers, Ashley Lu, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Kumar Poovathingal, Kristofer Davie, Dietmar Rudolf Thal, Keimpe D. B. Wierda, , Joris de Wit

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

bioRxiv · May 21, 2021 · PreprintNeuroscience

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, , Bart De Strooper

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

Cell · Jul 22, 2020Peer-reviewedNeuroscience

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

Annerieke S. R. Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesús Zoco, David L Blum, Luc Buée, Bart De Strooper, Mark W. E. J. Fiers

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.

EMBO Molecular Medicine · Jan 17, 2020Peer-reviewedNeuroscience