Author

An Snellinx

VIB-KU Leuven Center for Brain & Disease Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 7

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:differential expression· 5 Organism:human· 5 Organism:mouse· 5 Assay:spatial transcriptomics· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Bart De StrooperiD· 7 shared Mark W. E. J. FiersiD· 4 shared Amaia M. ArranziD· 3 shared Katleen CraessaertsiD· 3 shared Lutgarde SerneelsiD· 3 shared Alison GoateiD· 2 shared Anna Martínez‐MurianaiD· 2 shared Annerieke S. R. SierksmaiD· 2 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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7 shared papersNeuroscience

Bart De StrooperORCID

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7 papers

Recent·Most cited

The Alzheimer's therapeutic Lecanemab induces an amyloid-clearing program in microglia

Giulia Albertini, Magdalena Zielonka, Cuypers Marie-Lynn, An Snellinx, Ciana Xu, Poovathingal Suresh, Wojno Marta, Kristofer Davie, van Lieshout Veerle, Katleen Craessaerts, Leen Wolfs, Emanuela Pasciuto, Julia Tom, Katrien Horré, Lutgarde Serneels, , Bart De Strooper

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

bioRxiv · Jul 24, 2025 · PreprintNeuroscience

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Lutgarde Serneels, Annerieke S. R. Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Lekshmi Nair, Anna Martínez‐Muriana, An Snellinx, Bart De Strooper

The paper develops a new mouse model for human microglia transplantation to study neurodegenerative diseases and makes it publicly available.

Molecular Neurodegeneration · Mar 11, 2025Peer-reviewedNeuroscience

Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice

Joan Cruz-Sesé, Marta Miron-Alcala, María Alfonso-Triguero, Jon Olalde, Leire Ruiz, Nuria Galbis-Gramage, Lorea Cortes, Laura Escobar, Pranav Preman, An Snellinx, Takashi Saito, Takaomi C. Saido, Laura Saiz-Aúz, Alberto Rábano‐Gutierrez, Julia TCW, , Amaia M. Arranz

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

bioRxiv · Jan 28, 2025 · PreprintNeuroscience

Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells

Amy F. Lloyd, Anna Martínez‐Muriana, Emma Davis, Michael J. D. Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J. Brenes, Linda V. Sinclair, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark W. E. J. Fiers, Bart De Strooper, Andrew J.M. Howden

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

Cell Reports · Oct 25, 2024Peer-reviewedNeuroscience

Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer's disease

Sriram Balusu, Katrien Horré, Nicola Thrupp, An Snellinx, Lutgarde Serneels, Iordana Chrysidou, Amaia M. Arranz, Annerieke S. R. Sierksma, Joel Simrén, Thomas K. Karikari, Henrik Zetterberg, Wei-Ting Chen, Dietmar Rudolf Thal, Evgenia Salta, Mark W. E. J. Fiers, Bart De Strooper

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

bioRxiv · Feb 18, 2022 · PreprintNeuroscience

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, María Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart De Strooper, Amaia M. Arranz

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

Molecular Neurodegeneration · Sep 25, 2021Peer-reviewedNeuroscience

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, , Bart De Strooper

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

Cell · Jul 22, 2020Peer-reviewedNeuroscience