Author
Karolinska InstitutetORCID 0000-0002-1121-6072Unclaimed ORCID profile · follow to get notified of new preprints
12 papers
Recent·Most cited
Mónica Díez-Salguero, Lisbeth Harder, Marla Herr, M. Llorca-Torralba, Esther Berrocoso, Jens Hjerling‐Leffler, Ana B. Muñoz‐Manchado
This study identifies Pthlh-expressing interneurons in the striatum as critical for cognitive functions through genetic and functional analyses in mice.
bioRxiv · Dec 5, 2025 · PreprintNeuroscience
Juan M. Barba-Reyes, Lisbeth Harder, Sergio Marco Salas, Methasit Jaisa-aad, Clara Muñoz‐Castro, Leonardo D. Garma, Nima Rafati, Mats F. Nilsson, Bradley T. Hyman, Alberto Serrano‐Pozo, Ana B. Muñoz‐Manchado
The paper uses snRNA-seq and spatial transcriptomics to study oligodendroglia in Parkinson's disease, identifying disease-specific subclasses and transcriptomic changes linked to myelin integrity and cell communication.
Acta Neuropathologica · May 5, 2025Peer-reviewedNeuroscience
Manuel A. Sánchez-García, Nieves Lara-Ureña, Rosana March‐Díaz, Clara Ortega‐de San Luis, Silvia Quiñones-Cañete, Juan M. Barba-Reyes, Daniel Cabello-Rivera, Ana María Muñoz-Cabello, Bella Mora-Romero, Carmen Romero‐Molina, Antonio Heras‐Garvin, Victoria Navarro, José López‐Barneo, Marisa Vizuete, Javier Vitórica, , Alberto Pascual
This study identifies the PHD3-FOXO3 axis as a regulator of the interferon type I response in microglia, which contributes to Alzheimer's disease progression.
bioRxiv · Oct 1, 2024 · PreprintNeuroscience
Leonardo D. Garma, Lisbeth Harder, Juan M. Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats F. Nilsson, Alberto Serrano‐Pozo, Bradley T. Hyman, Ana B. Muñoz‐Manchado
The paper uses snRNA-seq to identify eight interneuron classes in the human dorsal striatum, validates markers with in situ hybridization, and compares them to mouse interneurons.
Nature Communications · Jul 22, 2024Peer-reviewedNeuroscience
Hermany Munguba, Kasra Nikouei, Hannah Hochgerner, Polina Oberst, Alexandra Kouznetsova, Jesper Ryge, Ana B. Muñoz‐Manchado, Jennie Close, Renata Batista‐Brito, Sten Linnarsson, Jens Hjerling‐Leffler
This study investigates the role of Sox6 in maintaining somatostatin interneuron subtype identity during migration, finding that its removal reduces subtype diversity in the mature cortex.
Neuron · Aug 24, 2023Peer-reviewedNeuroscience
Xiaoyan Qian, Kenneth D. Harris, Thomas Hauling, Dimitris Nicoloutsopoulos, Ana B. Muñoz‐Manchado, Nathan Skene, Jens Hjerling‐Leffler, Mats F. Nilsson
The paper introduces pciSeq to map inhibitory neurons in mouse hippocampus CA1, identifying 16 interneuron classes with spatial arrangement matching ground truth.
Nature Methods · Nov 18, 2019Peer-reviewedNeuroscience
Philip R. Jansen, Kyoko Watanabe, Sven Stringer, Nathan Skene, Julien Bryois, Anke R. Hammerschlag, Christiaan de Leeuw, Jeroen S. Benjamins, Ana B. Muñoz‐Manchado, Mats Nagel, Jeanne E. Savage, Henning W. Tiemeier, Tonya J.H. White, Joyce Y. Tung, David A. Hinds, , Daniëlle Posthuma
This study identifies 202 genome-wide significant loci for insomnia using a large sample, linking them to specific brain cell types and pathways.
Nature Genetics · Feb 25, 2019Peer-reviewedGenetics
Jeanne E. Savage, Philip R. Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B. Barr, Jonathan R. I. Coleman, Katrina L. Grasby, Anke R. Hammerschlag, Jakob André Kaminski, Robert Karlsson, Eva M. L. Krapohl, , Lene Christiansen
This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.
Nature Genetics · Jun 25, 2018Peer-reviewedGenetics
Mats Nagel, Philip R. Jansen, Sven Stringer, Kyoko Watanabe, Christiaan de Leeuw, Julien Bryois, Jeanne E. Savage, Anke R. Hammerschlag, Nathan Skene, Ana B. Muñoz‐Manchado, Tonya J.H. White, Henning W. Tiemeier, Sten Linnarsson, Jens Hjerling‐Leffler, Tinca J. C. Polderman, , Daniëlle Posthuma
This study conducts a large GWAS meta-analysis of neuroticism, identifying 136 novel genetic loci and 599 genes, with functional insights into brain regions and pathways.
Nature Genetics · Jun 22, 2018Peer-reviewedGenetics
Nathan Skene, Julien Bryois, Trygve E. Bakken, Gerome D. Breen, James J. Crowley, Héléna A. Gaspar, Paola Giusti‐Rodríguez, Rebecca D. Hodge, Jeremy A. Miller, Ana B. Muñoz‐Manchado, Michael C. O’Donovan, Michael John Owen, Antonio F. Pardiñas, Jesper Ryge, James Walters, , Jens Hjerling‐Leffler
The paper maps schizophrenia-associated genomic loci to specific brain cell types using single-cell RNA-sequencing data, finding consistent enrichment in pyramidal cells, medium spiny neurons, and interneurons.
Nature Genetics · May 20, 2018Peer-reviewedGenomics
Jonathan R. I. Coleman, Julien Bryois, Héléna A. Gaspar, Philip R. Jansen, Jeanne E. Savage, Nathan Skene, Robert J. Plomin, Ana B. Muñoz‐Manchado, Sten Linnarsson, Greg Crawford, Jens Hjerling‐Leffler, Patrick F. Sullivan, Daniëlle Posthuma, Gerome D. Breen
The paper identifies brain cell types and genes associated with intelligence using GWAS and single-cell gene expression data from a large cohort.
Molecular Psychiatry · Mar 8, 2018Peer-reviewedGenomics
Hoang T. Nguyen, Julien Bryois, April Kim, Amanda L. Dobbyn, Laura M. Huckins, Ana B. Muñoz‐Manchado, Douglas M. Ruderfer, Giulio Genovese, Menachem Fromer, Xinyi Xu, Dalila Pinto, Sten Linnarsson, Matthijs Verhage, August Benjamin Smit, Jens Hjerling‐Leffler, , Eli A. Stahl
The paper uses Bayesian modeling to analyze rare exonic variants in schizophrenia and neurodevelopmental disorders, identifying 1,551 risk genes for schizophrenia and 98 new risk genes for developmental disorders.
Genome Medicine · Dec 1, 2017Peer-reviewedGenomics