Gabriel Ichim

Lipid droplets sequester cell death effectors and delay regulated cell death execution

The paper shows lipid droplets delay regulated cell death by sequestering mitochondrial effectors like Bax, thereby reducing apoptosis execution in cancer and germ cells.

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity

This study identifies a non-apoptotic role for caspase-3 in melanoma cell motility by regulating coronin 1B activity, suggesting it as a potential target for anti-metastatic therapies.

Kremen1 dependence receptor induces SEC24C- and ATG9A-dependent autophagic cell death

This study shows Kremen1 induces autophagic cell death in cancer cells, dependent on SEC24C and ATG9A, contrasting with typical apoptosis.

Measuring nonapoptotic caspase activity with a transgenic reporter in mice

The paper develops a transgenic mouse model with a fluorescent caspase activity reporter to quantify nonapoptotic caspase activity in rodent brains and demonstrates its use in studying neurophysiological and stress-related effects.

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma cell lines

This study shows that in Caspase-8 deficient neuroblastoma cells, TLR3 activation leads to lysosomal cell death instead of apoptosis.

Minimal detection and low biological fluctuation of mitochondrial CpG methylation at the single-molecule level

This study develops a tool to detect mtDNA CpG methylation using long-read sequencing and finds low, stable levels across biological processes with limited variation.