Natalie Krahmer

Sympathetic signaling directs macrophage efferocytosis in thermogenic adipose tissue

The paper identifies norepinephrine as a trigger of macrophage efferocytosis in brown adipose tissue, linking sympathetic signaling to metabolic adaptation through β2-adrenergic and Axl/Mertk pathways.

EasyAb: A High-Throughput Workflow for Antibody-Based PTM Peptide Enrichment Method Coupled to Mass Spectrometry

EasyAb is a high-throughput workflow for antibody-based PTM peptide enrichment coupled to mass spectrometry, enhancing sensitivity for large-scale PTM analysis in diverse cell systems.

Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis

This study shows that DDI2 activates NFE2L1 to protect cells from ferroptosis by regulating the ubiquitin-proteasome system.

C-COMPASS: A Neural Network Tool for Multi-Omic Classification of Cell Compartments

C-COMPASS predicts protein and lipid localization across cellular compartments using neural networks, enabling multi-omic analysis of organelle dynamics in humanized liver mice.

A Spatiotemporal Proteomic Map of Human Adipogenesis

This study creates a spatiotemporal proteomic map of human adipogenesis, revealing changes in protein abundance, localization, and metabolic pathway reprogramming during adipocyte differentiation.

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19

This study shows SARS-CoV-2 spike protein accumulates in the skull-meninges-brain axis, causing brain cell death and long-term neurological effects.

Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

The paper introduces the Lipid Droplet Knowledge Portal, a resource integrating datasets on lipid droplet biology to uncover new determinants of lipid storage.

In vivo phosphoproteomics reveals pathogenic signaling changes in diabetic islets

The paper uses phosphoproteomics to identify signaling changes in diabetic islets, revealing GSK3's role in PDX1 and insulin secretion.