BiochemistrybioRxivPreprint
Expanding the Ligandable Chemical Space of OTUB1 through Discovery of a Four-Membered-Ring Recruiter Chemotype
Qiong Wu, Xiangyang Song, Li Chen…·Jian Jun Jin
The paper identifies a new four-membered-ring chemotype that selectively binds OTUB1, expands its ligandable chemical space, and enables the development of next-generation DUBTACs.