Yan Xiong

dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels

The paper introduces dubTAGs, small molecules that stabilize proteins tagged with FKBP12F36V by recruiting deubiquitinases, enabling tunable and reversible control of protein levels.

Expanding the Ligandable Chemical Space of OTUB1 through Discovery of a Four-Membered-Ring Recruiter Chemotype

The paper identifies a new four-membered-ring chemotype that selectively binds OTUB1, expands its ligandable chemical space, and enables the development of next-generation DUBTACs.

Targeting the NuRD Component, CHD4, Impairs Foxp3+ Treg Cell Production and Function and Promotes Anti-Tumor Immunity

This study shows that inhibiting CHD4, a component of the NuRD complex, reduces Treg cells and enhances antitumor immunity without causing autoimmunity.

Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads

This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells

This study investigates BCL11A DNA binding mechanisms, epigenetic regulation, and small-molecule effects on its expression in human erythrocyte precursor cells.

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.

A Genetic Pathway Composed of EDT1/HDG11, ERECTA, and E2Fa Loci Regulates Water Use Efficiency by Modulating Stomatal Density

The paper identifies a genetic pathway involving EDT1/HDG11, ERECTA, and E2Fa that regulates water use efficiency by reducing stomatal density through increased cell size.