Seppo Ylä-Herttuala

This study optimizes VSV-G-pseudotyped lentiviral transduction of NK cells by improving activation, construct design, and enhancer use, achieving high efficiency without compromising cell function.

This study evaluates engineered K562 feeder cells for enhancing NK cell expansion and function in ex vivo cultures, showing up to 500-fold higher yields compared to feeder-free systems.

The paper identifies drugs that rewiring the cancer-immune interface by enhancing NK cell function and tumor susceptibility through multimodal screening approaches.

This paper describes a GMP-compliant protocol for producing potent NK cells against AML and neuroblastoma using an automated platform, showing increased activation and killing efficacy.

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.