Preclinical Evaluation of P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging
Zhendong Song, Yinlong Li, Siyan Feng, Jiahui Chen, Xin Mu Zhou, Zhixu Zhang, Zhenkun Sun, Jian Rong, Chunyu Zhao, Ahmad F. Chaudhary, Jimmy S. Patel, Yabiao Gao, Thomas Lee Collier, Chongzhao Ran, Tyler S. Beyett, , Steven H. Liang
This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.
bioRxiv · Jan 16, 2025 · PreprintNeuroscience