iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype
Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry, Michael Kassiou
This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.
Journal of Neuroinflammation · Jan 4, 2024Peer-reviewedNeuroscience