MicrobiologyPNAS NexusPeer-reviewed
Mechanism of the Dual Action Self-Potentiating Antitubercular Drug Morphazinamide
Lev Ostrer, Taylor A. Crooks, Michael D. Howe…·Anthony D. Baughn
This study identifies a dual mechanism of action for morphazinamide, a more potent pyrazinamide analog, showing it kills Mycobacterium tuberculosis through coenzyme A disruption and aldehyde release, which also bypasses resistance.