Author

Michael D. Howe

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Anthony D. BaughniD· 3 shared Ziyi JiaiD· 3 shared Nathan A. SchachtiD· 2 shared Akanksha VarshneyiD· 1 shared Courtney C. AldrichiD· 1 shared Elise A. LamontiD· 1 shared Gebremichal GebretsadikiD· 1 shared Kenneth C. KeileriD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Anthony D. BaughnORCID

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Author profile →

3 papers

Recent·Most cited

Essential Role of MHC II in the Antitubercular Efficacy of Pyrazinamide

Elise A. Lamont, Shannon Lynn Kordus, Michael D. Howe, Ziyi Jia, Nathan A. Schacht, Muzafar Ahmad Rather, Gebremichal Gebretsadik, Anthony D. Baughn

This study shows that MHC II and CD4 T cell help are essential for pyrazinamide's antitubercular efficacy, revealing a host-mediated mechanism for its in vivo activity.

Antimicrobial Agents and Chemotherapy · Dec 19, 2025Peer-reviewedMicrobiology

Mechanism of the Dual Action Self-Potentiating Antitubercular Drug Morphazinamide

Lev Ostrer, Taylor A. Crooks, Michael D. Howe, Stephanie P. Vo, Ziyi Jia, Pooja V. Hegde, Nathan A. Schacht, Courtney C. Aldrich, Anthony D. Baughn

This study identifies a dual mechanism of action for morphazinamide, a more potent pyrazinamide analog, showing it kills Mycobacterium tuberculosis through coenzyme A disruption and aldehyde release, which also bypasses resistance.

PNAS Nexus · Jul 29, 2025Peer-reviewedMicrobiology

A trans-translation inhibitor is potentiated by zinc and kills Mycobacterium tuberculosis and non-tuberculous mycobacteria

Akanksha Varshney, Ziyi Jia, Michael D. Howe, Kenneth C. Keiler, Anthony D. Baughn

The paper shows that MBX-4132, a trans-translation inhibitor, kills Mycobacterium tuberculosis and non-tuberculous mycobacteria, with zinc enhancing its activity and iron reducing it.

ACS Infectious Diseases · Apr 9, 2025Peer-reviewedMicrobiology