Juan E. Abrahante

Cyclin D1 regulates the hepatic response to feeding: Evidence for non-cell cycle roles in the liver

This study shows cyclin D1 regulates hepatic gene networks and metabolic responses to feeding, with non-cell cycle roles in aging, MASLD, and C. elegans overnutrition.

Cholangiocytes' Primary Cilia Regulate DNA Damage Response and Repair

This study shows that primary cilia in cholangiocytes regulate DNA damage response and repair, with deciliated cells showing increased DNA damage and reduced survival under genotoxic stress.

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

The paper generates hiPSC-CM from male and female donors and finds sex dimorphism in calcium handling and gene expression without hormone exposure.

Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

This study shows that antiviral drugs fail to prevent neurological deficits in SARS-CoV-2-infected mice, which resemble neurodegenerative diseases due to chronic inflammation.

The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes

This study identifies the HH-GLI2-CKS1B network as a regulator of the proliferation-to-maturation transition in human cardiomyocytes, with implications for cardiac regeneration.

The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research

This paper presents the genome of the zebra mussel, Dreissena polymorpha, providing insights into its invasive success and creating a resource for invasive species research.

EditR: A novel base editing quantification software using Sanger sequencing

EditR quantifies base editing efficiency from Sanger sequencing data, offering accuracy and cost-effectiveness compared to existing methods.