Haofei Wang

GPTAnno provides a hierarchical cell type annotation method using GPT models and ontology trees, improving accuracy across species and tissues by integrating clustering with ontology constraints.

The paper creates a temporal and spatial atlas of postnatal heart development using single-nucleus transcriptomics and spatial transcriptomics, identifying 21 novel regulators of cardiomyocyte maturation through a new method called PIP-seq.

The paper identifies essential enhancers for pluripotency in mouse ES cells using a CRISPR-Cas9 screen and characterizes their target genes and regulatory networks.