Olivier Destaing

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

This study identifies HCK signaling as a driver of long-distance ECM degradation in macrophages through endo-exocytosis coupling involving MMPs and cathepsins.

This study identifies CYCLON as a nucleolar protein that regulates cancer cell fitness by controlling ribosome biogenesis and nucleolar structure across multiple tumor types.

This study uses optogenetic tools to reveal distinct functional roles of SRC and HCK kinases in macrophages, despite their redundancy.

This paper identifies a three-dimensional extracellular matrix cage formed by laminin and collagen IV that anchors megakaryocytes in the bone marrow and regulates their maturation and intravasation.

The paper presents a multiscale model of cancer cell invasion using PhysiBoSS, integrating spatial and intracellular processes to study migration modes and validate against experimental data.