Author

José Aguilar-Rodríguez

Stanford MedicineORCID 0000-0001-7622-5482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:plant (other)· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Daniel F. JarosziD· 2 shared Alexandria Van ElgortiD· 1 shared Christopher M. JakobsoniD· 1 shared Dmitri A. PetroviD· 1 shared Hunter B. FraseriD· 1 shared Jean C. C. VilaiD· 1 shared Manuel Razo‐MejiaiD· 1 shared Olivia M. GhoshiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersEvolutionary Biology

Daniel F. JaroszORCID

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2 papers

Recent·Most cited

Protein structure shapes natural genetic variation and de novo adaptation

Christopher M. Jakobson, Alexandria Van Elgort, José Aguilar-Rodríguez, Daniel F. Jarosz

The paper shows that protein structure predicts genetic variation and de novo adaptation by analyzing yeast, plants, and humans, and validates predictions with experimental evolution.

bioRxiv · Dec 22, 2025 · PreprintEvolutionary Biology

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

José Aguilar-Rodríguez, Jean C. C. Vila, Shi-An A. Chen, Manuel Razo‐Mejia, Olivia M. Ghosh, Daniel F. Jarosz, Hunter B. Fraser, Dmitri A. Petrov

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.

bioRxiv · Oct 30, 2024 · PreprintEvolutionary Biology