Christopher M. Jakobson

The paper shows that protein structure predicts genetic variation and de novo adaptation by analyzing yeast, plants, and humans, and validates predictions with experimental evolution.

The paper links genome to proteome in yeast progeny to identify variants controlling proteome diversity and predict their fitness effects under stress.

This study shows that the prion [BIG+] in yeast increases proliferation but reduces lifespan by altering protein synthesis and translational programs.

The paper proposes a spatially resolved kinetic model to explore optimal spatial organization strategies for biosynthetic pathways and finds that different pathways require distinct strategies based on kinetic and biophysical factors.

The paper shows that modifying shell proteins of bacterial microcompartments can improve metabolite diffusion and enhance pathway function in synthetic organelles.