Hunter B. Fraser

This study investigates how species-specific DNA methylation patterns arise, their functional consequences, and their role in natural selection, using human and chimpanzee methylation data.

The paper introduces FASTER, a method to detect accelerated evolution of function in genomic regions, finding more rapid evolution in conserved human sites linked to brain development and cognition.

The paper identifies a human-specific transcriptomic deletion in HMMR that affects cell division plasticity and links cortical expansion to cancer risk.

The paper identifies a human-accelerated neuron type linked to increased autism prevalence through evolutionary analysis of gene expression.

The paper decomposes evolutionary divergence into cell-intrinsic, extrinsic, and interaction components using reciprocal rat-mouse chimeras and finds cell-intrinsic factors dominate but extrinsic factors also play a role.

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.

The paper identifies differential gene regulation across human ancestries by analyzing chromatin activity and finds enhancers show stronger selection signals than promoters.

The paper identifies pervasive gene-by-environment interactions among natural genetic variants in yeast using high-throughput genome editing.

The paper identifies cis-regulatory variation in MRL mice associated with ear regeneration using allele-specific expression analysis.

The paper identifies transcriptome diversity as a major source of systematic bias in RNA-seq data and shows it explains significant variability in gene expression across organisms and datasets.

The paper maps QTLs for TCF21 binding, chromatin accessibility, and chromosomal looping in coronary artery smooth muscle cells and links them to CAD GWAS loci.

The paper catalogs somatic mutations across 36 tissues from 7,500 samples, revealing tissue-specific mutation profiles and selection pressures.

This study fine-maps cis-regulatory variants across diverse human populations by analyzing chromatin accessibility QTLs and their effects on gene expression and long-range interactions.

The paper identifies cis-regulatory divergence in eloF as a driver of sexual isolation in Drosophila by analyzing RNA-seq data from hybrids of D. simulans and D. sechellia.

The paper identifies spatially varying cis-regulatory divergence in Drosophila embryos by analyzing allele-specific gene expression and validates a mutation in a Bicoid binding site using CRISPR-Cas9.

This study maps cis-regulatory variation in budding yeast with high-resolution eQTLs, revealing roles of non-promoter variants and selection pressures on gene expression.

This study identifies genetic variants linked to age-related gene expression changes in the human brain and links them to neurodegenerative diseases.

This study introduces phylogenetic expression profiling (PEP) to detect gene sets with correlated expression across species, revealing functional relationships and novel gene roles in diseases.