Hagen Sülzen

The paper presents the cryo-EM structure of the human 20S proteasome bound to marizomib, revealing its binding mode and irreversible inhibitory mechanism.

This paper introduces SH-01, a novel recombinant protein that selectively inhibits the complement alternative pathway, showing efficacy in preventing PNH-related erythrocyte lysis and reduced infection risk compared to current treatments.

This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.