Martin Zoltner

This study maps the luminal proteome of the ER and Golgi in T. brucei using TurboID proximity biotinylation, identifying TbMANF as a novel modulator of ER stress tolerance in African trypanosomes.

This study characterizes the trypanosome mRNA decapping enzyme ALPH1, showing it preferentially cleaves non-m7G-capped RNAs and produces diphosphate-RNA.

This study shows that Trypanosoma brucei lacks a functional EJC and NMD pathway due to intron loss and gene redundancy.

The paper uses expansion microscopy and proximity labeling to reveal an asymmetric nuclear pore structure in trypanosomes, identifying unique and conserved components involved in mRNA export.

This paper introduces SH-01, a novel recombinant protein that selectively inhibits the complement alternative pathway, showing efficacy in preventing PNH-related erythrocyte lysis and reduced infection risk compared to current treatments.

This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.