Bacterial Aminopeptidase-Activated Peptide Prodrug Enables Species-Selective Targeting of Pseudomonas aeruginosa
Qingtian Gong, Silvia A. Synowsky, Aisling Lynch, John R. F. B. Connolly, Neeladri Sekhar Roy, Sally L. Shirran, Megan Bergkessel, Marc C. Devocelle, Clarissa Melo Czekster
This paper designs and tests aminopeptidase-activated AMP prodrugs that selectively target Pseudomonas aeruginosa, showing improved antimicrobial activity and reduced cross-resistance.
ACS Infectious Diseases · Aug 20, 2026Peer-reviewedMicrobiology