Sally L. Shirran

This study identifies AnkA as a bacterial effector that directly targets the WAVE Regulatory Complex and actin cytoskeleton, using molecular mimicry to subvert host cell functions during infection.

This paper designs and tests aminopeptidase-activated AMP prodrugs that selectively target Pseudomonas aeruginosa, showing improved antimicrobial activity and reduced cross-resistance.

This study elucidates the mechanism of YRDC catalysis, showing that threonine stabilizes the enzyme and dimerization is critical for function, with disease-linked mutations disrupting these processes.

This study identifies cytoplasmic androgen receptor (AR) localization and novel AR protein interactions in AI-resistant breast cancer, linking them to metabolic shifts and poor prognosis.

The paper combines TurboID and Co-IP to study protein interactions, showing how they complement each other in capturing transient and stable interactions in cell culture systems.

The paper reports the cryo-EM structure of the H-pilus, revealing its cyclic pilin subunit and explaining its role in conjugation.