Silvia A. Synowsky

Direct targeting of the WAVE-regulatory complex and the actin cytoskeleton by the Anaplasma phagocytophilum effector, AnkA

This study identifies AnkA as a bacterial effector that directly targets the WAVE Regulatory Complex and actin cytoskeleton, using molecular mimicry to subvert host cell functions during infection.

Bacterial Aminopeptidase-Activated Peptide Prodrug Enables Species-Selective Targeting of Pseudomonas aeruginosa

This paper designs and tests aminopeptidase-activated AMP prodrugs that selectively target Pseudomonas aeruginosa, showing improved antimicrobial activity and reduced cross-resistance.

Investigating the Interactomic Landscape of Survival Motor Neurons (SMN) and the SMN Δ7 truncated protein

The paper combines TurboID and Co-IP to study protein interactions, showing how they complement each other in capturing transient and stable interactions in cell culture systems.

Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament

This study characterizes the structure and mechanism of NdasCDO, a flavin-dependent cyclodipeptide oxidase, revealing its promiscuous substrate scope and reaction mechanism.