Clarissa Melo Czekster

This study determines the crystal structure of PIVS409A, revealing how the Cap region autoinhibits PIV and how it becomes activated through an intramolecular process.

This paper designs and tests aminopeptidase-activated AMP prodrugs that selectively target Pseudomonas aeruginosa, showing improved antimicrobial activity and reduced cross-resistance.

This study elucidates the mechanism of YRDC catalysis, showing that threonine stabilizes the enzyme and dimerization is critical for function, with disease-linked mutations disrupting these processes.

The paper designs improved nucleoside 2'-deoxyribosyltransferase enzymes with enhanced catalytic efficiency and broad substrate promiscuity for generating diverse nucleoside products.

This study characterizes the structure and mechanism of NdasCDO, a flavin-dependent cyclodipeptide oxidase, revealing its promiscuous substrate scope and reaction mechanism.

This paper demonstrates the immobilization of NDT enzymes from extremophiles to enhance their stability, recyclability, and catalytic efficiency for nucleoside synthesis.

This paper immobilizes a cyclodipeptide synthase on three supports to enable stable, recyclable production of the cyclic dipeptide cHE, demonstrating the feasibility of using immobilized enzymes with complex substrates.