Yuchen Gao

This study uses CRISPR-EChO to investigate HP1's role in organizing chromatin at supranucleosomal scales, revealing its ability to compact chromatin and repress transcription over large genomic regions.

The paper describes a reporter system to quantify durable CRISPR-based gene silencing and reports a single CRISPR protein capable of producing long-lasting gene repression.

This paper introduces CRISPR ChaCha, a GPCR-Coupled CRISPR-Cas system that converts extracellular signals into genetic programs, showing improved performance over existing systems.