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This study identifies the NLGN3-CSPG4-PIEZO1 axis as a regulator of glial precursor cell state and glioma proliferation through mechanosensitive signaling.

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

This study shows that BDNF-TrkB signaling promotes malignant synaptic plasticity in gliomas, enhancing tumor progression through mechanisms similar to long-term potentiation in the healthy brain.

The paper describes a reporter system to quantify durable CRISPR-based gene silencing and reports a single CRISPR protein capable of producing long-lasting gene repression.