Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewed
Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity
Hu Zhu, Jason Michael Conley, Karavadhi Surendra…·Samarjit Patnaik
The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.