Author

Jason Michael Conley

Indiana University IndianapolisORCID 0000-0003-4201-4112Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Hongxia ReniD· 2 shared Val J. WattsiD· 2 shared Adriano MarcheseiD· 1 shared Alexander JochimiD· 1 shared Candice S. KlugiD· 1 shared Carmella Evans‐MolinaiD· 1 shared Hongmao SuniD· 1 shared Hu Zhu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

Hongxia RenORCID

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3 papers

Recent·Most cited

BiochemistryCommunications BiologyPeer-reviewedJan 7, 2026

Distinct Membrane Binding Properties of the Two Non-visual Arrestins

Thomas D. Killeen, Katelyn R. Tepper, Kyle W. Miller…·Qiuyan Chen

This study compares the membrane-binding properties of arrestin-2 and arrestin-3 using biophysical and cell-based methods, revealing distinct lipid interaction mechanisms and activation dynamics.

3 citationstop 5%

fluorescence / live-cell microscopybiophysical modeling

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Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedMay 22, 2025

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

Hu Zhu, Jason Michael Conley, Karavadhi Surendra…·Samarjit Patnaik

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

12 citations

experimental assaydrug response / drug discovery

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Molecular BiologyBiomoleculesPeer-reviewedDec 25, 2024

G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells

Jason Michael Conley, Alexander Jochim, Carmella Evans‐Molina…·Hongxia Ren

This study investigates how GPR17 inhibits GLP-1 secretion in enteroendocrine cells through Gi/o-dependent signaling, using pharmacological and genetic approaches.

9 citations

mouseexperimental assay

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