Author

Samarjit Patnaik

National Center for Advancing Translational SciencesORCID 0000-0002-4265-7620Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Matthew D. HalliD· 2 shared Min SheniD· 2 shared Alexandra PopaiD· 1 shared Amy Q. WangiD· 1 shared Andrew G. ReidenbachiD· 1 shared Brian Erickson· 1 shared Craig Braun· 1 shared Cristina Rosa FerroneiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

Matthew D. HallORCID

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Author profile →

3 papers

Recent·Most cited

Phenotypic screening for small molecules that lower PrP in cultured cells

Jeannine A. Frei, Andrew G. Reidenbach, Leo MH Xu, Raja Mohan Gopalakrishnan, Dominick Casalana, Daniel A. Sprague, Mark A. Bray, Amy Q. Wang, Vanessa Laversenne, Brian Erickson, Craig Braun, Samarjit Patnaik, Mckenzie Hall, Douglas S. Auld, Sonia M. Vallabh

The paper identifies two small molecules that lower PrP levels in cultured cells but show limited activity in human cell lines and in vivo.

Molecular and Cellular Neuroscience · Jul 9, 2026Peer-reviewedNeuroscience

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

Hu Zhu, Jason Michael Conley, Karavadhi Surendra, Justin E. LaVigne, Val J. Watts, Hongmao Sun, Min Shen, Matthew D. Hall, Hongxia Ren, Samarjit Patnaik

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

European Journal of Medicinal Chemistry · May 22, 2025Peer-reviewedPharmacology & Toxicology

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qibiao Wu, Yuanli Zhen, Robert Tyler Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, , Nabeel M. Bardeesy

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

Cancer Discovery · May 12, 2025Peer-reviewedCancer Biology