Author

Hongmao Sun

National Center for Advancing Translational SciencesORCID 0000-0003-4042-6498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Hongxia ReniD· 1 shared Hu Zhu· 1 shared Jason Michael ConleyiD· 1 shared Jinghua Zhao· 1 shared Justin E. LaVigneiD· 1 shared Karavadhi Surendra· 1 shared Kennie Cruz-Gutierrez· 1 shared Matthew D. HalliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

Hongxia RenORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedMay 22, 2025

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

Hu Zhu, Jason Michael Conley, Karavadhi Surendra…·Samarjit Patnaik

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

12 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedJun 2, 2022

Retro Drug Design: From Target Properties to Molecular Structures

Yuhong Wang, Sam Michael, Shyh‐Ming Yang…·Hongmao Sun

This paper introduces retro drug design (RDD), an AI method to generate novel small molecule drugs with desired properties, and demonstrates its ability to produce compounds with biological activity and BBB permeability.

24 citations

deep learningdrug response / drug discovery

𝕏 PostBluesky