Cancer BiologyNature CommunicationsPeer-reviewed
Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma
Konstantinos V. Floros, Carter K. Fairchild, Jinxiu Li…·Anthony C. Faber
This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.