Author

Heather Hook

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Trevor SiggersiD· 3 shared David Bray· 2 shared Jessica L. KeenaniD· 2 shared Rose W. Zhao· 2 shared Ahmed YoussefiD· 1 shared Andrew EmiliiD· 1 shared Ashley R. PenvoseiD· 1 shared Brian RaughtiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Trevor SiggersORCID

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Author profile →

3 papers

Recent·Most cited

Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation

Melissa M. Inge, Rebekah Miller, Heather Hook, David Bray, Jessica L. Keenan, Rose W. Zhao, Thomas D. Gilmore, Trevor Siggers

The paper introduces CoRec, a method to profile TF-COF complexes, revealing KAT-TF interactions and their role in H3K27ac regulation.

Nucleic Acids Research · Aug 14, 2024Peer-reviewedMolecular Biology

A multi-tiered map of EMT defines major transition points and identifies vulnerabilities

Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon, Heather Hook, Gopal Karemore, Michael UJ Oliphant, Weiwei Lin, Qian Liu, Sadhna Phanse, Carl A. White, Dzmitry Padhorny, Sergei Kotelnikov, Guillaume P. Andrieu, Christopher S. Chen, , Andrew Emili

The paper maps EMT transitions through multi-omic profiling, identifies key regulatory factors, and reveals discordance between molecular layers in human mammary epithelial cells.

bioRxiv · Jun 1, 2021 · PreprintSystems Biology

Customizable high-throughput platform for profiling cofactor recruitment to DNA to characterize cis-regulatory elements and screen non-coding single-nucleotide polymorphisms

David Bray, Heather Hook, Rose W. Zhao, Jessica L. Keenan, Ashley R. Penvose, Yemi Osayame, Nima Mohaghegh, Trevor Siggers

The paper introduces CASCADE, a high-throughput platform to profile cofactor recruitment to DNA variants, identifying key regulators and ETS sites in macrophages.

bioRxiv · Apr 21, 2020 · PreprintGenomics