Thomas J. Silhavy

This study shows that outer membrane fluidity and mechanics in Gram-negative bacteria can be independently controlled by altering lipid composition and crosslinking.

The paper quantifies protein turnover in E. coli under 12 conditions, revealing cytoplasmic protein recycling under nitrogen limitation and identifying unknown proteolysis pathways.

The paper identifies YhdP as a modulator of phospholipid transport rate in Escherichia coli, showing its role in controlling inner membrane shrinkage and outer membrane rupture during mlaA* mutation.