Andrew Tinker

Pathways regulating the excitability of sympathetic neurons derived from human induced pluripotent stem cells

This paper uses hiPSC-derived sympathetic neurons to study pathways regulating neuronal excitability and finds that GIRK channels mediate inhibitory effects of adrenergic and muscarinic receptors.

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes

This paper describes a protocol to generate parasympathetic neurons from hiPSC that exhibit native electrophysiological properties and modulate hiPSC-atrial cardiomyocyte activity.

An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort

This study investigates epigenomic changes in left and right atria of atrial fibrillation patients compared to controls, identifying dysregulated loci and epigenetic mechanisms.