Laura Fedele

Pathways regulating the excitability of sympathetic neurons derived from human induced pluripotent stem cells

This paper uses hiPSC-derived sympathetic neurons to study pathways regulating neuronal excitability and finds that GIRK channels mediate inhibitory effects of adrenergic and muscarinic receptors.

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes

This paper describes a protocol to generate parasympathetic neurons from hiPSC that exhibit native electrophysiological properties and modulate hiPSC-atrial cardiomyocyte activity.

A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain.

This paper identifies Pdgfrb+ fibroblast and mural cells as contributors to neuropathic pain by showing their increased numbers and expression of pro-algesic mediators in a mouse model.

Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors

This study shows JAK inhibitors block RA synovial fluid-induced sensory neuron activation by inhibiting STAT3 phosphorylation and pain gene expression.

Modelling inflammation-induced peripheral sensitization in a dish - more complex than expected?

The paper investigates the effects of inflammatory soup on sensory neuron excitability using human and mouse models, finding minimal changes and suggesting that in vitro modeling of peripheral sensitization is complex.

Mice lacking the cAMP effector protein POPDC1 show enhanced hippocampal synaptic plasticity

This study shows that POPDC1 knockout mice have enhanced hippocampal long-term potentiation, suggesting POPDC1 modulates cAMP signaling in synaptic plasticity.