Franziska Denk

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

This study uses scRNA-seq to compare fibroblast subtypes in keloid and normal skin tissues with cultured fibroblasts, finding that some disease-associated features persist in vitro.

This paper describes a protocol to generate parasympathetic neurons from hiPSC that exhibit native electrophysiological properties and modulate hiPSC-atrial cardiomyocyte activity.

This paper identifies Pdgfrb+ fibroblast and mural cells as contributors to neuropathic pain by showing their increased numbers and expression of pro-algesic mediators in a mouse model.

This study shows JAK inhibitors block RA synovial fluid-induced sensory neuron activation by inhibiting STAT3 phosphorylation and pain gene expression.

This study uses in vivo calcium imaging and home cage monitoring to assess joint neuron activity and locomotor behavior in mouse arthritis models, finding increased spontaneous activity in AIA mice but not PMX mice.

The paper investigates the effects of inflammatory soup on sensory neuron excitability using human and mouse models, finding minimal changes and suggesting that in vitro modeling of peripheral sensitization is complex.

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.

This study uses in vivo calcium imaging to show that satellite glial cells show increased activity in painful states, with some signals linked to neuronal firing and others occurring independently.

This paper assesses spontaneous sensory neuron activity using in vivo calcium imaging and develops a machine learning algorithm to predict spontaneous activity with high accuracy across different pain models and labs.

This review examines spontaneous activity in peripheral sensory nerves in neuropathic pain, finding broad agreement on its presence but highlighting variability and uncertainty due to methodological differences.

This study compares the transcriptional response of satellite glial cells to nerve injury using single-cell RNA-seq and identifies a common signature involving cholesterol biosynthesis regulation.

This study investigates Nav1.7's role in axonal propagation in nociceptors using sodium channel blockers in mice, finding it essential in about 2/3 of C-fibre neurons and a lower proportion of muscle-innervating neurons.

This paper systematically reviews the literature on fibroblasts in chronic pain, finding limited research and proposing a new model for their role in peripheral neuron sensitization.

The paper characterizes immune responses in a neuropathic pain mouse model and develops a web-based tool for transcriptional data-mining of peripheral neuroimmune interactions.

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.

This study investigates how bone cancer affects the peripheral encoding of mechanical pressure stimuli by comparing sensory afferent responses in healthy and cancer-induced bone pain rats.